1687 Boston Measles 

1690 New York Yellow Fever 

1713 Boston Measles 

1729 Boston Measles 

1732-3 Worldwide Influenza 

1738 South Carolina Smallpox 

1739-40 Boston Measles 

1747 CT, NY, PA, SC Measles 

1759 North America [areas inhabited by white people] Measles 

1761 N. Amer and West Indies Influenza 

1772 North America Measles 

1775 North America [especially hard in NE] Unknown epidemic 

1775-6 Worldwide [one of the worst epidemics] Influenza 

1783 Dover, DE ["extremely fatal"] Bilious Disorder 

1788 Philadelphia and New York Measles 

1793 Vermont [a "putrid" fever] and Influenza 

1793 VA [killed 500 in 5 counties in 4 weeks] Influenza 

1793 Philadelphia [one of the worst epidemics] Yellow Fever 

1793 Harrisburg, PA [many unexplained deaths] Unknown 

1793 Middletown, PA [many mysterious deaths] Unknown 

1794 Philadelphia, PA Yellow Fever 

1796-7 Philadelphia, PA Yellow Fever

1798 Philadelphia, PA [one of the worst] Yellow Fever 

1803 New York Yellow Fever 

1820-3 Nationwide [starts-Schuylkill River and spreads] "Fever" 

1831-2 Nationwide [brought by English emigrants] Asiatic Cholera 

1832 NY City and other major cities Cholera 

1833 Columbus, OH Cholera 

1834 New York City Cholera 

1837 Philadelphia Typhus 

1841 Nationwide [especially severe in the south] Yellow Fever 

1847 New Orleans Yellow Fever 

1847-8 Worldwide Influenza 

1848-9 North America Cholera 

1849 New York Cholera 

1850 Nationwide Yellow Fever 

1850-1 North America Influenza 

1851 Coles Co., IL, The Great Plains, and Missouri Cholera 

1852 Nationwide [New Orleans-8,000 die in summer] Yellow Fever 

1855 Nationwide [many parts] Yellow Fever 

1857-9 Worldwide [one of the greated epidemics] Influenza 

1860-1 Pennsylvania Smallpox 

1865-73 Philadelphia, NY, Boston, New Orleans Smallpox Baltimore, 
Memphis, Washington DC Cholera - [A series of recurring epidemics 
of: Typhus Typhoid Scarlet Fever Yellow Fever 

1873-5 North America and Europe Influenza 

1878 New Orleans [last great epidemic] Yellow Fever 

1885 Plymouth, PA Typhoid 

1886 Jacksonville, FL Yellow Fever